Looking for Fat-Containing Food Ideas?

People with CF pictured
may or may not be
taking TRIKAFTA.

Every dose of TRIKAFTA® must be taken with a meal or snack that contains fat to help your body absorb the medicine. You can get some delicious food ideas below or head straight to CF Kitchen on Everyday-CF.com. Remember to talk to your healthcare provider or dietitian before making any changes to your diet.

Kate, age 29

F508del/F508del

Easy ways to add fat to your foods
Pour on extra-virgin olive oil Spread on butter
Mix in sliced almonds Mash in avocado
Easy ways to add fat to your foods
Pour on extra-virgin olive oil
Spread on butter
Mix in sliced almonds
Mash in avocado
Morning meals Evening meals
Whole-milk cheese sandwich Tater tot bake
Oatmeal with whole milk, almonds, and fruit Macaroni and cheese
Bagel with peanut butter Quesadilla with whole-milk cheese
Whole-milk yogurt sweetened with sliced fresh fruit Pasta with pesto sauce
Chocolate chip pancakes Whole-milk cheese pizza
Morning meals
Whole-milk cheese sandwich
Oatmeal with whole milk, almonds, and fruit
Bagel with peanut butter
Whole-milk yogurt sweetened with sliced fresh fruit
Chocolate chip pancakes
Evening meals
Tater tot bake
Macaroni and cheese
Quesadilla with whole-milk cheese
Pasta with pesto sauce
Whole-milk cheese pizza
Quick meals for when you're on the go
Chocolate pudding Strawberry whole-milk yogurt milkshake
Whole-milk mozzarella cheese Peanut butter with celery
Hard-boiled eggs  
Quick meals for when you're on the go
Chocolate pudding
Strawberry whole-milk yogurt milkshake
Whole-milk mozzarella cheese
Peanut butter with celery
Hard-boiled eggs
 

These lists are not intended to be complete.

Visit fdc.nal.usda.gov for foods and their fat content.

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA because they may affect the amount of TRIKAFTA in your body.

Recipe Ideas

Everyday CF logo

Get more delicious recipes and food ideas.
Visit CF Kitchen on Everyday-CF.com

Looking for something specific in the CF Kitchen?
Choose a mealtime below.

BREAKFAST   LUNCH   DINNER  

Everyday-CF.com is an educational website developed by Vertex Pharmaceuticals Incorporated.

Keep Learning About TRIKAFTA

Learn how to take TRIKAFTA
Get TRIKAFTA resources, all in one place

Important Safety Information and Indication

Información Importante de Seguridad e Indicación

EXPAND

AMPLIAR

COLLAPSE

REDUCIR

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Important Safety Information  

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Important Safety Information

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

 

¿Qué es TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor e ivacaftor)?TRIKAFTA es un medicamento recetado que se usa para el tratamiento de la fibrosis quística (FQ) en pacientes de 6 años o más que presentan al menos una copia de la mutación F508del en el gen regulador de la conductancia transmembrana de la fibrosis quística (cystic fibrosis transmembrane conductance regulator, CFTR) u otra mutación que responda al tratamiento con TRIKAFTA.

¿Qué es TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor e ivacaftor)?

TRIKAFTA es un medicamento recetado que se usa para el tratamiento de la fibrosis quística (FQ) en pacientes de 6 años o más que presentan al menos una copia de la mutación F508del en el gen regulador de la conductancia transmembrana de la fibrosis quística (cystic fibrosis transmembrane conductance regulator, CFTR) u otra mutación que responda al tratamiento con TRIKAFTA.

Hable con su médico para saber si usted presenta una mutación del gen de la FQ indicada.

Se desconoce si TRIKAFTA es seguro y eficaz en niños menores de 6 años.

Información Importante de Seguridad  

No tome TRIKAFTA si está tomando ciertos medicamentos, por ejemplo:

  • antibióticos como rifampicina (RIFAMATE®, RIFATER®) o rifabutina (MYCOBUTIN®)
  • medicamentos para las convulsiones como fenobarbital, carbamazepina (TEGRETOL®, CARBATROL®, EQUETRO®), o fenitoína (DILANTIN®, PHENYTEK®)
  • hierba de San Juan

Hable con su médico antes de tomar TRIKAFTA si toma algunos de los medicamentos o suplementos a base de hierbas que se mencionan antes.

¿Qué es TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor e ivacaftor)?

TRIKAFTA es un medicamento recetado que se usa para el tratamiento de la fibrosis quística (FQ) en pacientes de 6 años o más que presentan al menos una copia de la mutación F508del en el gen regulador de la conductancia transmembrana de la fibrosis quística (cystic fibrosis transmembrane conductance regulator, CFTR) u otra mutación que responda al tratamiento con TRIKAFTA.

Hable con su médico para saber si usted presenta una mutación del gen de la FQ indicada.

Se desconoce si TRIKAFTA es seguro y eficaz en niños menores de 6 años.

Información Importante de Seguridad

No tome TRIKAFTA si está tomando ciertos medicamentos, por ejemplo:

  • antibióticos como rifampicina (RIFAMATE®, RIFATER®) o rifabutina (MYCOBUTIN®)
  • medicamentos para las convulsiones como fenobarbital, carbamazepina (TEGRETOL®, CARBATROL®, EQUETRO®), o fenitoína (DILANTIN®, PHENYTEK®)
  • hierba de San Juan

Hable con su médico antes de tomar TRIKAFTA si toma algunos de los medicamentos o suplementos a base de hierbas que se mencionan antes.

Antes de tomar TRIKAFTA, infórmele al médico sobre todas sus afecciones médicas, incluido lo siguiente:

  • Si tiene problemas renales
  • Si tiene o ha tenido problemas hepáticos
  • Si está embarazada o planea quedar embarazada. Se desconoce si TRIKAFTA dañará a su bebé nonato. Usted y su médico deben decidir si tomará TRIKAFTA durante el embarazo
  • Si está amamantando o planea amamantar. Se desconoce si TRIKAFTA pasa a la leche materna. Usted y su médico deben decidir si tomará TRIKAFTA mientras amamanta

TRIKAFTA puede afectar el modo en que funcionan otros medicamentos, y otros medicamentos pueden afectar la forma en que funciona TRIKAFTA.

Infórmele al médico sobre todos los medicamentos que toma, incluidos los medicamentos recetados y de venta libre, las vitaminas y los suplementos a base de hierbas. Es posible que la dosis de TRIKAFTA se deba ajustar cuando se toma con ciertos medicamentos.

Pídale a su médico o farmacéutico una lista de estos medicamentos si no está seguro. Asegúrese de que la lista incluya medicamentos de todas las farmacias si tiene más de una.

En especial, debe informarle al médico si toma:

  • medicamentos antifúngicos, que incluyen ketoconazol (como NIZORAL®), itraconazol (como SPORANOX®), posaconazol (como NOXAFIL®), voriconazol (como VFEND®) o fluconazol (como DIFLUCAN®)
  • antibióticos, que incluyen telitromicina (como KETEK®), claritromicina (como BIAXIN®) o eritromicina (como ERY-TAB®)
  • otros medicamentos, que incluyen rifampicina, rifabutina, fenobarbital, carbamazepina, fenitoína y hierba de San Juan

Conozca los medicamentos que toma. Lleve una lista de sus medicamentos para mostrársela a su médico y al farmacéutico cuando obtenga un medicamento nuevo.

¿Qué debo evitar mientras tomo TRIKAFTA?

  • TRIKAFTA puede provocar mareos en algunas personas que lo toman. No conduzca automóviles, no utilice maquinaria ni realice ninguna actividad que requiera que esté alerta hasta saber de qué forma lo afecta TRIKAFTA
  • Evite los alimentos y las bebidas que contengan toronja (pomelo) mientras toma TRIKAFTA

¿Cuáles son los posibles efectos secundarios de TRIKAFTA?

TRIKAFTA puede provocar efectos secundarios graves, incluidos los siguientes:

  • Daño hepático y deterioro de la función hepática en personas con enfermedades graves del hígado que podrían volverse serias y requerir trasplante. También hubo casos de daño hepático en personas sin antecedentes de enfermedades del hígado.
  • Los aumentos de las enzimas hepáticas en la sangre son un efecto secundario frecuente en personas tratadas con TRIKAFTA. Estos pueden ser graves y pueden ser un signo de daño hepático. El médico le realizará análisis de sangre para controlar el hígado:
  • antes de comenzar a tomar TRIKAFTA
  • cada 3 meses durante el primer año de tomar TRIKAFTA
  • cada año mientras está tomando TRIKAFTA

Es posible que el médico le realice análisis de sangre para controlar el hígado con mayor frecuencia si ha presentado aumentos de las enzimas hepáticas en la sangre en el pasado.

Llame al médico inmediatamente si presenta algunos de los siguientes síntomas de problemas hepáticos:

  • dolor o malestar en el área (abdominal) superior derecha del estómago
  • color amarillo en la piel o en la parte blanca de los ojos
  • pérdida del apetito
  • náuseas o vómitos
  • orina oscura y de color ámbar
  • Anomalías en el cristalino del ojo (catarata) han ocurrido en algunos niños y adolescentes que recibieron tratamiento con TRIKAFTA. Si es niño o adolescente, su médico debe realizar exámenes oculares antes del tratamiento con TRIKAFTA, y durante este, para ver si tiene cataratas

Los efectos secundarios más frecuentes de TRIKAFTA incluyen:

  • dolor de cabeza
  • infección de las vías respiratorias superiores (resfrío común), incluidas congestión y secreción nasal
  • dolor de estómago (abdominal)
  • diarrea
  • erupción
  • aumento en las enzimas hepáticas
  • aumento en una enzima de la sangre llamada creatina fosfocinasa
  • gripe (influenza)
  • inflamación de los senos paranasales
  • aumento de la bilirrubina en sangre

Estos no son todos los posibles efectos secundarios de TRIKAFTA. Llame al médico para obtener asesoramiento médico acerca de los efectos secundarios. Le recomendamos informar los efectos secundarios a la Administración de Alimentos y Medicamentos (Food and Drug Administration, FDA) al teléfono 1-800-FDA-1088.

Para obtener información adicional consulte la Información de Prescripción completa, incluida la Información para el Paciente.

 

 

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Important Safety Information

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

 

Antes de tomar TRIKAFTA, infórmele al médico sobre todas sus afecciones médicas, incluido lo siguiente:

  • Si tiene problemas renales
  • Si tiene o ha tenido problemas hepáticos
  • Si está embarazada o planea quedar embarazada. Se desconoce si TRIKAFTA dañará a su bebé nonato. Usted y su médico deben decidir si tomará TRIKAFTA durante el embarazo
  • Si está amamantando o planea amamantar. Se desconoce si TRIKAFTA pasa a la leche materna. Usted y su médico deben decidir si tomará TRIKAFTA mientras amamanta

TRIKAFTA puede afectar el modo en que funcionan otros medicamentos, y otros medicamentos pueden afectar la forma en que funciona TRIKAFTA.

Infórmele al médico sobre todos los medicamentos que toma, incluidos los medicamentos recetados y de venta libre, las vitaminas y los suplementos a base de hierbas. Es posible que la dosis de TRIKAFTA se deba ajustar cuando se toma con ciertos medicamentos.

Pídale a su médico o farmacéutico una lista de estos medicamentos si no está seguro. Asegúrese de que la lista incluya medicamentos de todas las farmacias si tiene más de una.

En especial, debe informarle al médico si toma:

  • medicamentos antifúngicos, que incluyen ketoconazol (como NIZORAL®), itraconazol (como SPORANOX®), posaconazol (como NOXAFIL®), voriconazol (como VFEND®) o fluconazol (como DIFLUCAN®)
  • antibióticos, que incluyen telitromicina (como KETEK®), claritromicina (como BIAXIN®) o eritromicina (como ERY-TAB®)
  • otros medicamentos, que incluyen rifampicina, rifabutina, fenobarbital, carbamazepina, fenitoína y hierba de San Juan

Conozca los medicamentos que toma. Lleve una lista de sus medicamentos para mostrársela a su médico y al farmacéutico cuando obtenga un medicamento nuevo.

¿Qué debo evitar mientras tomo TRIKAFTA?

  • TRIKAFTA puede provocar mareos en algunas personas que lo toman. No conduzca automóviles, no utilice maquinaria ni realice ninguna actividad que requiera que esté alerta hasta saber de qué forma lo afecta TRIKAFTA
  • Evite los alimentos y las bebidas que contengan toronja (pomelo) mientras toma TRIKAFTA

¿Cuáles son los posibles efectos secundarios de TRIKAFTA?

TRIKAFTA puede provocar efectos secundarios graves, incluidos los siguientes:

  • Daño hepático y deterioro de la función hepática en personas con enfermedades graves del hígado que podrían volverse serias y requerir trasplante. También hubo casos de daño hepático en personas sin antecedentes de enfermedades del hígado.
  • Los aumentos de las enzimas hepáticas en la sangre son un efecto secundario frecuente en personas tratadas con TRIKAFTA. Estos pueden ser graves y pueden ser un signo de daño hepático. El médico le realizará análisis de sangre para controlar el hígado:
  • antes de comenzar a tomar TRIKAFTA
  • cada 3 meses durante el primer año de tomar TRIKAFTA
  • cada año mientras está tomando TRIKAFTA

Es posible que el médico le realice análisis de sangre para controlar el hígado con mayor frecuencia si ha presentado aumentos de las enzimas hepáticas en la sangre en el pasado.

Llame al médico inmediatamente si presenta algunos de los siguientes síntomas de problemas hepáticos:

  • dolor o malestar en el área (abdominal) superior derecha del estómago
  • color amarillo en la piel o en la parte blanca de los ojos
  • pérdida del apetito
  • náuseas o vómitos
  • orina oscura y de color ámbar
  • Anomalías en el cristalino del ojo (catarata) han ocurrido en algunos niños y adolescentes que recibieron tratamiento con TRIKAFTA. Si es niño o adolescente, su médico debe realizar exámenes oculares antes del tratamiento con TRIKAFTA, y durante este, para ver si tiene cataratas

Los efectos secundarios más frecuentes de TRIKAFTA incluyen:

  • dolor de cabeza
  • infección de las vías respiratorias superiores (resfrío común), incluidas congestión y secreción nasal
  • dolor de estómago (abdominal)
  • diarrea
  • erupción
  • aumento en las enzimas hepáticas
  • aumento en una enzima de la sangre llamada creatina fosfocinasa
  • gripe (influenza)
  • inflamación de los senos paranasales
  • aumento de la bilirrubina en sangre

Estos no son todos los posibles efectos secundarios de TRIKAFTA. Llame al médico para obtener asesoramiento médico acerca de los efectos secundarios. Le recomendamos informar los efectos secundarios a la Administración de Alimentos y Medicamentos (Food and Drug Administration, FDA) al teléfono 1-800-FDA-1088.

Para obtener información adicional consulte la Información de Prescripción completa, incluida la Información para el Paciente.

 

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Important Safety Information  

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

 

What is Trikafta? 

What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 6 years of age.

Important safety information  

Important Safety Information

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.
 

Do not take TRIKAFTA if you take certain medicines such as:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort

Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.
 

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one. 

Especially tell your doctor if you take:

  • antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
  • other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

What should I avoid while taking TRIKAFTA?

  • TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.