Christian, age 16
F508del/2307insA

Christian, age 16
F508del/2307insA

Christian, age 16
F508del/2307insA

People with CF pictured have taken TRIKAFTA and
were compensated for their participation.

People with CF pictured have taken TRIKAFTA and
were compensated for their participation.

Who TRIKAFTA® is For

 

 

Are you eligible for TRIKAFTA?

  • At least one F508del mutation
  • Or at least one other mutation in the CF gene that is responsive to TRIKAFTA

People with CF pictured have taken TRIKAFTA and were compensated for their participation.

Who TRIKAFTA® is For

Are you eligible for TRIKAFTA?

  • At least one F508del mutation
  • Or at least one other mutation in the CF gene that is responsive to TRIKAFTA

Check your

Check your

Check your

Eligibility

Eligibility

Eligibility

 

Enter your mutations in the boxes below to see if at least one of them makes you eligible for TRIKAFTA. You can also use the mutation chart below.

Enter your mutations in the boxes below to see if at least one of them makes you eligible for TRIKAFTA. You can also use the mutation chart below.

Enter your mutations in the boxes below to see if at least one of them makes you eligible for TRIKAFTA. You can also use the mutation chart below.

Age:

2 years or older
    Learn how to enter 2 or more mutations

    Most people with CF have 2 CF mutations, 1 on each copy of the CF gene. However, in rare instances, 1 copy of the CF gene can have more than 1 mutation. This is called a compound, or complex, mutation.

    To enter 2 or more mutations into 1 entry field, separate them with a semicolon, space, comma, or forward slash. For example, if your mutations are R74W/V201M/D1270N and W1282R, use the Mutation 1 field to enter: R74W; V201M; D1270N and the Mutation 2 field to enter: W1282R.

    If you don’t know your or your loved one's CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if TRIKAFTA could be right for you.

    If you don’t know your or your loved one's CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if TRIKAFTA could be right for you.

    If you don’t know your or your loved one's CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if TRIKAFTA could be right for you.

    Based on the information entered, you may be eligible for TRIKAFTA.

    Talk with your healthcare provider to see if TRIKAFTA is right for you.

    Talk with your healthcare provider to see if TRIKAFTA is right for you.

    Talk with your healthcare provider to see if TRIKAFTA is right for you.

    Here is some information about TRIKAFTA that may be helpful:
    See the study results
    Learn about potential side effects
    Learn how TRIKAFTA works
    Hear April's eligibility story

    Neither CF gene mutation you entered is eligible for TRIKAFTA.

    Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.

    You can view the list of eligible mutations here.

    We’re sorry; we do not recognize 1 or both of the mutations you entered.
    Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.
    View the list of eligible TRIKAFTA mutations.

    See which mutations

    See which mutations

    See which mutations

    Trikafta is indicated for

    Trikafta is indicated for

    Trikafta is indicated for

     

    TRIKAFTA is for the treatment of CF in people age 2 years and older who have at least one copy of the F508del mutation or
    one of the following CF gene mutations.* If you don't see your mutation in this chart, try using the tool above or talk to your
    healthcare provider.

    TRIKAFTA is for the treatment of CF in people age 2 years and older who have at least one copy of the F508del mutation or one of the following CF gene mutations.* If you don't see your mutation in this chart, try using the tool above or talk to your healthcare provider.

    TRIKAFTA is for the treatment of CF in people age 2 years and older who have at least one copy of the F508del mutation or one of the following CF gene mutations.* If you don't see your mutation in this chart, try using the tool above or talk to your healthcare provider.

    TRIKAFTA is for the treatment of CF in people age 2 years and older who have at least one copy of the F508del mutation or one of the following CF gene mutations.* If you don't see your mutation in this chart, try using the tool above or talk to your healthcare provider.

    1

    • 1898+3A->G
    • 1341G->A
    • 1507_1515del9

    2

    • 2789+5G->A
    • 2752-26A->G
    • 2789+2insA
    • 296+28A->G
    • 2183A->G

    3

    • 3272-26A->G
    • 3849+10kbC->T
    • 3141del9
    • 3600G->A
    • 3041-15T->G
    • 3849+40A->G
    • 3849+4A->G
    • 3850-3T->G

    4

    • 4005+2T->C

    5

    • 546insCTA
    • 5T;TG12
    • 5T;TG13

    6

    • 621+3A->G

    7

    • 711+3A->G

    A

    • A1067T
    • A455E
    • A46D
    • A349V
    • A1006E
    • A120T
    • A234D
    • A554E
    • A1067P
    • A309D
    • A62P
    • A107G

    C

    • C491R

    D

    • D110E
    • D110H
    • D1152H
    • D1270N
    • D579G
    • D443Y
    • D924N
    • D192G
    • D979V
    • D614G
    • D836Y
    • D1445N
    • D565G
    • D993Y
    • D443Y;G576A;R668C

    E

    • E193K
    • E56K
    • E831X
    • E474K
    • E116K
    • E60K
    • E588V
    • E92K
    • E403D
    • E822K
    • E116Q
    • E292K

    F

    • F508del
    • F1052V
    • F1074L
    • F311L
    • F575Y
    • F1099L
    • F508C
    • F311del
    • F191V
    • F1016S
    • F1107L
    • F200I
    • F587I
    • F508C;S1251N

    G

    • G1069R
    • G1244E
    • G1349D
    • G178R
    • G551D
    • G551S
    • G85E
    • G1061R
    • G480C
    • G27R
    • G463V
    • G628R
    • G622D
    • G126D
    • G970D
    • G194R
    • G314E
    • G194V
    • G576A
    • G1249R
    • G178E
    • G1047R
    • G27E
    • G480S
    • G1123R
    • G1247R
    • G424S
    • G970S
    • G576A;R668C
    • G551A

    H

    • H139R
    • H1085R
    • H1085P
    • H939R
    • H1375P
    • H1054D
    • H199Y
    • H620P
    • H620Q
    • H939R;H949L

    I

    • I502T
    • I618T
    • I175V
    • I1366N
    • I601F
    • I980K
    • I1269N
    • I1027T
    • I148T
    • I336K
    • I807M
    • I148N
    • I1139V
    • I105N
    • I125T
    • I331N
    • I506L
    • I556V

    K

    • K1060T
    • K162E
    • K464E

    L

    • L206W
    • L1077P
    • L165S
    • L1335P
    • L967S
    • L320V
    • L346P
    • L1324P
    • L997F
    • L15P
    • L453S
    • L1480P
    • L137P
    • L441P
    • L333F
    • L619S
    • L333H
    • L1011S

    M

    • M1101K
    • M265R
    • M152V
    • M952I
    • M952T
    • M1137V
    • M150K

    N

    • N1303K
    • N1088D
    • N1303I
    • N186K
    • N187K
    • N418S

    P

    • P67L
    • P5L
    • P205S
    • P574H
    • P750L
    • P140S
    • P499A

    Q

    • Q98R
    • Q1291R
    • Q237E
    • Q237H
    • Q359R
    • Q372H
    • Q552P
    • Q1313K
    • Q493R

    R

    • R1070Q
    • R1070W
    • R117C
    • R117H
    • R347H
    • R352Q
    • R74W
    • R347P
    • R117G
    • R170H
    • R334L
    • R117L
    • R31L
    • R933G
    • R352W
    • R117P
    • R258G
    • R751L
    • R347L
    • R1283S
    • R1162L
    • R553Q
    • R792G
    • R1066H
    • R668C
    • R334Q
    • R1283M
    • R75Q
    • R74Q
    • R297Q
    • R31C
    • R75L
    • R1048G
    • R555G
    • R709Q
    • R516S
    • R74W;V201M;D1270N
    • R74W;D1270N
    • R74W;V201M
    • R117C;G576A;R668C

    S

    • S1251N
    • S1255P
    • S549N
    • S549R
    • S945L
    • S977F
    • S13F
    • S1159F
    • S912L
    • S1159P
    • S589N
    • S341P
    • S492F
    • S1118F
    • S737F
    • S364P
    • S1235R
    • S1045Y
    • S108F
    • S549I

    T

    • T1053I
    • T1036N
    • T338I
    • T1246I
    • T1086I
    • T351I
    • T1299I

    V

    • V456A
    • V456F
    • V201M
    • V562I
    • V1153E
    • V1240G
    • V1293G
    • V754M
    • V232D
    • V392G
    • V603F

    W

    • W361R
    • W1098C
    • W1282R

    Y

    • Y563N
    • Y161D
    • Y109N
    • Y1014C
    • Y161S
    • Y1032C
    • Y301C

    *Predicted to respond to TRIKAFTA based on results from clinical and/or laboratory settings.

    *Predicted to respond to TRIKAFTA based on results from clinical and/or laboratory settings.

    *Predicted to respond to TRIKAFTA based on results from clinical and/or laboratory settings.

    Xander, age 27

    F508del/F508del

    Xander, age 27

    F508del/F508del

    Xander, age 27

    F508del/F508del

    KEEP LEARNING

    ABOUT TRIKAFTA

    ABOUT TRIKAFTA

    ABOUT TRIKAFTA

    Learn how TRIKAFTA works See TRIKAFTA results

    What is TRIKAFTA® (elexacaftor/tezacaftor/ ivacaftor and ivacaftor)?

    TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in people aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    Talk to your healthcare provider to learn if you have an indicated CF gene mutation.

    It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

    IMPORTANT SAFETY INFORMATION

    What is the most important information I should know about TRIKAFTA?

    TRIKAFTA can cause serious liver damage and liver failure. Liver failure leading to transplantation and death has been seen in some people with or without a history of liver problems taking TRIKAFTA.

    Your healthcare provider will do blood tests to check your liver:

    • before you start TRIKAFTA
    • then every month during your first 6 months of taking TRIKAFTA 
    • then every 3 months during the next 12 months of taking TRIKAFTA 
    • then at least every year while you are taking TRIKAFTA

     

    Your healthcare provider may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past or are experiencing signs or symptoms of liver injury.

    Stop taking TRIKAFTA and call your healthcare provider right away if you have any of the following symptoms of liver problems:

    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)
    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)

    What should I tell my healthcare provider before taking TRIKAFTA?

    Before taking TRIKAFTA, tell your healthcare provider about all of your medical conditions, including if you:

    • have or have had liver problems
    • are allergic to TRIKAFTA or any ingredients in TRIKAFTA. See the end of the Medication Guide for a complete list of ingredients in TRIKAFTA
    • have kidney problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your healthcare provider should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your healthcare provider should decide if you will take TRIKAFTA while you are breastfeeding

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

    Especially tell your healthcare provider if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible or reasonably likely side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • See “What is the most important information I should know about TRIKAFTA?”
    • Serious Allergic Reactions can happen to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
    • rash or hives
    • tightness of the chest or throat or difficulty breathing
    • swelling of the face, lips, and/or tongue, or difficulty swallowing
    • light-headedness or dizziness
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your healthcare provider should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin
    • constipation 

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Medication Guide with Important Warning.

    Arrow icon arrow icon

    Recursos 
    en Español

    Recursos 
    en Español

    Recursos en Español

    Important Safety Information, including Important Warning, and Indication

    Información Importante de Seguridad e Indicación

    EXPAND

    AMPLIAR

    COLLAPSE

    REDUCIR

    What is TRIKAFTA® (elexacaftor/tezacaftor/ ivacaftor and ivacaftor)?

    TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in people aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    Talk to your healthcare provider to learn if you have an indicated CF gene mutation.

    It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

    IMPORTANT SAFETY INFORMATION

    What is the most important information I should know about TRIKAFTA?

    TRIKAFTA can cause serious liver damage and liver failure. Liver failure leading to transplantation and death has been seen in some people with or without a history of liver problems taking TRIKAFTA.

    Your healthcare provider will do blood tests to check your liver:

    • before you start TRIKAFTA
    • then every month during your first 6 months of taking TRIKAFTA 
    • then every 3 months during the next 12 months of taking TRIKAFTA 
    • then at least every year while you are taking TRIKAFTA

     

    Your healthcare provider may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past or are experiencing signs or symptoms of liver injury.

    Stop taking TRIKAFTA and call your healthcare provider right away if you have any of the following symptoms of liver problems:

    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)
    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)

    What should I tell my healthcare provider before taking TRIKAFTA?

    Before taking TRIKAFTA, tell your healthcare provider about all of your medical conditions, including if you:

    • have or have had liver problems
    • are allergic to TRIKAFTA or any ingredients in TRIKAFTA. See the end of the Medication Guide for a complete list of ingredients in TRIKAFTA
    • have kidney problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your healthcare provider should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your healthcare provider should decide if you will take TRIKAFTA while you are breastfeeding

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

    Especially tell your healthcare provider if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible or reasonably likely side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • See “What is the most important information I should know about TRIKAFTA?”
    • Serious Allergic Reactions can happen to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
    • rash or hives
    • tightness of the chest or throat or difficulty breathing
    • swelling of the face, lips, and/or tongue, or difficulty swallowing
    • light-headedness or dizziness
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your healthcare provider should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin
    • constipation 

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Medication Guide with Important Warning.

     

    Your healthcare provider may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past or are experiencing signs or symptoms of liver injury.

    Stop taking TRIKAFTA and call your healthcare provider right away if you have any of the following symptoms of liver problems:

    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)
    • pain, swelling, or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • mental changes
    • nausea or vomiting
    • dark, amber-colored urine
    • loss of appetite
    • fluid in your stomach area (ascites)

    What should I tell my healthcare provider before taking TRIKAFTA?

    Before taking TRIKAFTA, tell your healthcare provider about all of your medical conditions, including if you:

    • have or have had liver problems
    • are allergic to TRIKAFTA or any ingredients in TRIKAFTA. See the end of the Medication Guide for a complete list of ingredients in TRIKAFTA
    • have kidney problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your healthcare provider should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your healthcare provider should decide if you will take TRIKAFTA while you are breastfeeding

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

    Especially tell your healthcare provider if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible or reasonably likely side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • See “What is the most important information I should know about TRIKAFTA?”
    • Serious Allergic Reactions can happen to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
    • rash or hives
    • tightness of the chest or throat or difficulty breathing
    • swelling of the face, lips, and/or tongue, or difficulty swallowing
    • light-headedness or dizziness
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your healthcare provider should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin
    • constipation 

    Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Medication Guide with Important Warning.