Check Your Eligibility
TRIKAFTA is for people age 6 years and older with at least one F508del mutation or at least one other mutation in the CF gene that is responsive to TRIKAFTA. Enter your mutations to see if at least one of them is eligible.
Most people with CF have 2 CF mutations, 1 on each copy of the CF gene. However, in rare instances, 1 copy of the CF gene can have more than 1 mutation. This is called a compound, or complex, mutation.
To enter 2 or more mutations into 1 entry field, separate them with a semicolon, space, comma, or forward slash. For example, if your mutations are R74W/V201M/D1270N and W1282R, use the Mutation 1 field to enter: R74W; V201M; D1270N and the Mutation 2 field to enter: W1282R.
If you don’t know your or your child's CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if TRIKAFTA could be right for you.
Based on the information entered, you may be eligible for TRIKAFTA.
Talk with your healthcare provider to see if TRIKAFTA is right for you.
Neither CF gene mutation you entered is eligible for TRIKAFTA.
Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.
We’re sorry, we do not recognize 1 or both of the mutations you entered.
Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.
You can view the list of eligible TRIKAFTA mutations here.
Brenna and Taylor share what their TRIKAFTA experience has meant to them, advice for others who may be considering it, and what they're looking forward to.
Get answers to common questions, such as:
- How does TRIKAFTA work?
- What are the study details and results?
- What are the possible side effects?
Personalized support—for whatever is up next
Vertex GPSTM offers eligible patients personalized, one-on-one support from day 1. Your dedicated Support Specialist has the tools, experience, and expertise to help your loved one reach their treatment goals. They'll walk you through each step and help you navigate things like insurance coverage and financial assistance options.
But that's just the start. Your Support Specialist will stay in touch so they can meet your loved one's needs, whatever stage they are at.
What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.
What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?
TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.
Talk to your doctor to learn if you have an indicated CF gene mutation.
It is not known if TRIKAFTA is safe and effective in children under 6 years of age.
Important Safety Information
Do not take TRIKAFTA if you take certain medicines such as:
- antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
- seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
- St. John’s wort
Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.
¿Qué es TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor e ivacaftor)?TRIKAFTA es un medicamento recetado que se usa para el tratamiento de la fibrosis quística (FQ) en pacientes de 6 años o más que presentan al menos una copia de la mutación F508del en el gen regulador de la conductancia transmembrana de la fibrosis quística (cystic fibrosis transmembrane conductance regulator, CFTR) u otra mutación que responda al tratamiento con TRIKAFTA.
¿Qué es TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor e ivacaftor)?
TRIKAFTA es un medicamento recetado que se usa para el tratamiento de la fibrosis quística (FQ) en pacientes de 6 años o más que presentan al menos una copia de la mutación F508del en el gen regulador de la conductancia transmembrana de la fibrosis quística (cystic fibrosis transmembrane conductance regulator, CFTR) u otra mutación que responda al tratamiento con TRIKAFTA.
Hable con su médico para saber si usted presenta una mutación del gen de la FQ indicada.
Se desconoce si TRIKAFTA es seguro y eficaz en niños menores de 6 años.
Información Importante de Seguridad
No tome TRIKAFTA si está tomando ciertos medicamentos, por ejemplo:
- antibióticos como rifampicina (RIFAMATE®, RIFATER®) o rifabutina (MYCOBUTIN®)
- medicamentos para las convulsiones como fenobarbital, carbamazepina (TEGRETOL®, CARBATROL®, EQUETRO®), o fenitoína (DILANTIN®, PHENYTEK®)
- hierba de San Juan
Hable con su médico antes de tomar TRIKAFTA si toma algunos de los medicamentos o suplementos a base de hierbas que se mencionan antes.
What is Trikafta?
What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?
What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?
TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.
Talk to your doctor to learn if you have an indicated CF gene mutation.
It is not known if TRIKAFTA is safe and effective in children under 6 years of age.
Important safety information
Important Safety Information
Do not take TRIKAFTA if you take certain medicines such as:
- antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
- seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
- St. John’s wort
Talk to your doctor before taking TRIKAFTA if you take any of the medicines or herbal supplements listed above.
Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:
- have kidney problems
- have or have had liver problems
- are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding
TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.
Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one.
Especially tell your doctor if you take:
- antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
- antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
- other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What should I avoid while taking TRIKAFTA?
- TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
- Avoid food or drink that contains grapefruit while you are taking TRIKAFTA
What are the possible side effects of TRIKAFTA?
TRIKAFTA can cause serious side effects, including:
- Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
- High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
- before you start TRIKAFTA
- every 3 months during your first year of taking TRIKAFTA
- every year while you are taking TRIKAFTA
Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
Call your doctor right away if you have any of the following symptoms of liver problems:
- pain or discomfort in the upper right stomach (abdominal) area
- yellowing of your skin or the white part of your eyes
- loss of appetite
- nausea or vomiting
- dark, amber-colored urine
- Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts
The most common side effects of TRIKAFTA include:
- headache
- upper respiratory tract infection (common cold) including stuffy and runny nose
- stomach (abdominal) pain
- diarrhea
- rash
- increase in liver enzymes
- increase in a certain blood enzyme called creatine phosphokinase
- flu (influenza)
- inflamed sinuses
- increase in blood bilirubin
These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
Do not take TRIKAFTA if you take certain medicines such as:
Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:
- have kidney problems
- have or have had liver problems
- are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding
TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.
Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one.
Especially tell your doctor if you take:
- antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
- antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
- other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What should I avoid while taking TRIKAFTA?
- TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
- Avoid food or drink that contains grapefruit while you are taking TRIKAFTA
What are the possible side effects of TRIKAFTA?
TRIKAFTA can cause serious side effects, including:
- Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
- High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
- before you start TRIKAFTA
- every 3 months during your first year of taking TRIKAFTA
- every year while you are taking TRIKAFTA
Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
Call your doctor right away if you have any of the following symptoms of liver problems:
- pain or discomfort in the upper right stomach (abdominal) area
- yellowing of your skin or the white part of your eyes
- loss of appetite
- nausea or vomiting
- dark, amber-colored urine
- Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts
The most common side effects of TRIKAFTA include:
- headache
- upper respiratory tract infection (common cold) including stuffy and runny nose
- stomach (abdominal) pain
- diarrhea
- rash
- increase in liver enzymes
- increase in a certain blood enzyme called creatine phosphokinase
- flu (influenza)
- inflamed sinuses
- increase in blood bilirubin
These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:
- have kidney problems
- have or have had liver problems
- are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
- are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding
TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.
Ask your doctor or pharmacist for a list of these medicines if you are not sure. Make sure the list includes medicines from all your pharmacies, if you have more than one.
Especially tell your doctor if you take:
- antifungal medicines including ketoconazole (such as NIZORAL®), itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
- antibiotics including telithromycin (such as KETEK®), clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)
- other medicines including rifampin, rifabutin, phenobarbital, carbamazepine, phenytoin, and St. John’s wort
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
What should I avoid while taking TRIKAFTA?
- TRIKAFTA can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how TRIKAFTA affects you
- Avoid food or drink that contains grapefruit while you are taking TRIKAFTA
What are the possible side effects of TRIKAFTA?
TRIKAFTA can cause serious side effects, including:
- Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
- High liver enzymes in the blood is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
- before you start TRIKAFTA
- every 3 months during your first year of taking TRIKAFTA
- every year while you are taking TRIKAFTA
Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
Call your doctor right away if you have any of the following symptoms of liver problems:
- pain or discomfort in the upper right stomach (abdominal) area
- yellowing of your skin or the white part of your eyes
- loss of appetite
- nausea or vomiting
- dark, amber-colored urine
- Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts
The most common side effects of TRIKAFTA include:
- headache
- upper respiratory tract infection (common cold) including stuffy and runny nose
- stomach (abdominal) pain
- diarrhea
- rash
- increase in liver enzymes
- increase in a certain blood enzyme called creatine phosphokinase
- flu (influenza)
- inflamed sinuses
- increase in blood bilirubin
These are not all the possible side effects of TRIKAFTA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.