Now approved For people with cystic fibrosis (CF)
as young as 2 years old

with at least one F508del mutation or at
least one other mutation that is responsive
to TRIKAFTA®

with at least one F508del mutation or at
least one other mutation that is responsive
to TRIKAFTA®

with at least one F508del mutation or at
least one other mutation that is responsive
to TRIKAFTA®

Hear stories from the TRIKAFTA community:

Jen, caring for a
son living with CF

TRIKAFTA is very meaningful to us because it's the first modulator he's qualified for.

 

Jen, caring for son Clayton, who is living with CF

Image of Blair, a TRIKAFTA patient

Blair, caring for a
son living with CF

Because we were informed and trusted our CF care team, it made the decision easier.

 

Blair, caring for son Thomas, who is living with CF

Image of Stacey, a TRIKAFTA patient

Stacey, caring for a
son living with CF

He's living his life with CF on his terms, that's for sure. And he won't let CF hold him back.

 

Stacey, caring for son Massimo, who is living with CF

Image of Olivia, a TRIKAFTA patient

Olivia, age 26
F508del/F508del

The most meaningful
part of my journey with TRIKAFTA so far has been seeing how my friends and family react to my progress.

The most meaningful
part of my journey with TRIKAFTA so far has been seeing how my friends and family react to my progress.

The most meaningful
part of my journey with TRIKAFTA so far has been seeing how my friends and family react to my progress.

Olivia

Age 26,
F508del/F508del

Image of Jason, a TRIKAFTA patient

Jason, age 41
F508del/N1303K

Staying on track with TRIKAFTA is what helps me continue to move forward.

Jason

Age 41,
F508del/N1303K

Image of Taylor, a TRIKAFTA patient

Taylor, age 28
F508del/F508del

With TRIKAFTA, I
still have CF, of course. But now I am so much more than that. CF doesn't have to define me.

Taylor

Age 28,
F508del/F508del

Image of Brenna, a TRIKAFTA patient

Brenna, age 22
F508del/F508del

To finally see and

feel these results with TRIKAFTA has been what I hoped for.

Brenna

Age 22,
F508del/F508del

Image of Candi, a TRIKAFTA patient

Candi, age 35
F508del/F508del

Taking TRIKAFTA was the right decision for me. And I’m not taking it for granted.

 

Candi

Age 35,
F508del/F508del

Image of April, a TRIKAFTA patient

April, age 28
F508del/1154insTC

I’ve waited basically my entire life for something like this.

 

April

Age 28,
F508del/1154insTC

People with CF pictured may or may not be taking TRIKAFTA.

CF will always be part of the equation, but you know there’s more to who you are.
Ask your doctor about making TRIKAFTA part of the equation—a triple combination therapy that treats the underlying cause.


TRIKAFTA is a breakthrough treatment for people with CF age 2 years and older with at least one
copy of the F508del mutation or at least one other mutation that is responsive to TRIKAFTA.

TRIKAFTA is a breakthrough treatment for people with CF age 2 years and older with at least one
copy of the F508del mutation or at least one other mutation that is responsive to TRIKAFTA.

TRIKAFTA is a breakthrough treatment for people with CF age 2 years and older with at least one copy of the F508del mutation or at least one other mutation that is responsive to TRIKAFTA.

Check Your Eligibility

TRIKAFTA is for people with CF age 2 years and older with at least one F508del mutation or at least one other mutation that is responsive to TRIKAFTA. Enter your mutations to see if at least one of them is eligible.

Age:

2 years or older

    Most people with CF have 2 CF mutations, 1 on each copy of the CF gene. However, in rare instances, 1 copy of the CF gene can have more than 1 mutation. This is called a compound, or complex, mutation.

    To enter 2 or more mutations into 1 entry field, separate them with a semicolon, space, comma, or forward slash. For example, if your mutations are R74W/V201M/D1270N and W1282R, use the Mutation 1 field to enter: R74W; V201M; D1270N and the Mutation 2 field to enter: W1282R.

    If you don’t know your or your loved one's CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if TRIKAFTA could be right for you.

    You can view the list of eligible mutations here.

    Based on the information entered, you may be eligible for TRIKAFTA.

    Talk with your healthcare provider to see if TRIKAFTA is right for you.

    Here is some information about TRIKAFTA that may be helpful:

    Neither CF gene mutation you entered is eligible for TRIKAFTA.

    Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.

    You can view the list of eligible mutations here.

    We’re sorry, we do not recognize 1 or both of the mutations you entered.
    Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.
    You can view the list of eligible TRIKAFTA mutations here.

    trk stories thumbnail
    Hear from people who take TRIKAFTA
    Over 20,500 people age 6 years and older have been prescribed TRIKAFTA.* Here are a few of their stories.
    Hear from people who take TRIKAFTA
    Over 20,500 people age 6 years and older have been prescribed TRIKAFTA.* Here are a few of their stories.
    Hear from people who take TRIKAFTA
    Over 20,500 people age 6 years and older have been prescribed TRIKAFTA.* Here are a few of their stories.

    Based on prescriptions shipped from specialty pharmacies in the US as of February 3, 2023. Data does not include patients’ CF gene mutations and does not reflect patients who have stopped treatments.

    Watch TRIKAFTA stories
    View the TRIKAFTA Brochure, updated to include information for caregivers of children with CF age 2 through 5
    The TRIKAFTA Brochure

    Get answers to common questions, such as:

    • How does TRIKAFTA work?
    • What are the study details and results?
    • What are the possible side effects?
    View the brochure

    Important Safety Information and Indication

    Información Importante de Seguridad e Indicación

    EXPAND

    AMPLIAR

    COLLAPSE

    REDUCIR

    What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

    TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    Talk to your doctor to learn if you have an indicated CF gene mutation.

    It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

    Important Safety Information  

    Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

    • have kidney problems
    • have or have had liver problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

    What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

    TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    Talk to your doctor to learn if you have an indicated CF gene mutation.

    It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

    Important Safety Information

    Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

    • have kidney problems
    • have or have had liver problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

    Especially tell your doctor if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
    • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
    • before you start TRIKAFTA
    • every 3 months during your first year of taking TRIKAFTA
    • every year while you are taking TRIKAFTA

    Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

    Call your doctor right away if you have any of the following symptoms of liver problems:

    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin

    Tell your doctor if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Patient Information.

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

    Especially tell your doctor if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
    • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
    • before you start TRIKAFTA
    • every 3 months during your first year of taking TRIKAFTA
    • every year while you are taking TRIKAFTA

    Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

    Call your doctor right away if you have any of the following symptoms of liver problems:

    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin

    Tell your doctor if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Patient Information.

     

     

     

    What is Trikafta? 

    What is TRIKAFTA® (elexacaftor/tezacaftor/ivacaftor and ivacaftor)?

    TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

    Talk to your doctor to learn if you have an indicated CF gene mutation.

    It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

    Important safety information  

    Important Safety Information

    Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

    • have kidney problems
    • have or have had liver problems
    • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
    • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines.

    TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

    Especially tell your doctor if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
    • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
    • before you start TRIKAFTA
    • every 3 months during your first year of taking TRIKAFTA
    • every year while you are taking TRIKAFTA

    Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

    Call your doctor right away if you have any of the following symptoms of liver problems:

    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin

    Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Patient Information.
     

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

    Especially tell your doctor if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
    • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
    • before you start TRIKAFTA
    • every 3 months during your first year of taking TRIKAFTA
    • every year while you are taking TRIKAFTA

    Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

    Call your doctor right away if you have any of the following symptoms of liver problems:

    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin

    Tell your doctor if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Patient Information.
     

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

    Especially tell your doctor if you take:

    • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
    • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
    • St. John’s wort
    • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
    • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

    Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

    What should I avoid while taking TRIKAFTA?

    • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

    What are the possible side effects of TRIKAFTA?

    TRIKAFTA can cause serious side effects, including:

    • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
    • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
    • before you start TRIKAFTA
    • every 3 months during your first year of taking TRIKAFTA
    • every year while you are taking TRIKAFTA

    Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

    Call your doctor right away if you have any of the following symptoms of liver problems:

    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
    • Abnormality of the eye lens (cataract) has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

    The most common side effects of TRIKAFTA include:

    • headache
    • upper respiratory tract infection (common cold) including stuffy and runny nose
    • stomach (abdominal) pain
    • diarrhea
    • rash
    • increase in liver enzymes
    • increase in a certain blood enzyme called creatine phosphokinase
    • flu (influenza)
    • inflamed sinuses
    • increase in blood bilirubin

    Tell your doctor if you have any side effect that bothers you or that does not go away.

    These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

    For further information, please see full Prescribing Information, including Patient Information.