TRIKAFTA™ is a breakthrough treatment for people
with cystic fibrosis (CF) age 12 years and older with at least one copy
of the F508del mutation.


CF will always be part of the equation, but you know there's more
to who you are.

Make TRIKAFTA part of your equation—a triple combination therapy
that treats the underlying cause.

TRIKAFTA™ is a breakthrough
treatment for people with
cystic fibrosis (CF) age 12 years
and older with at least one copy
of the F508del mutation.


CF will always be part of the equation,
but you know there's more
to who you are.

Make TRIKAFTA part
of your equation—a triple
combination therapy that treats
the underlying cause.

Megan, age 20
F508del/621+1G→T
The TRIKAFTA Brochure

Get answers to common questions, such as:

  • How does TRIKAFTA work?

  • What are the study details and results?

  • What are the possible side effects?

April's TRIKAFTA Story

Watch April share her experience with TRIKAFTA and living with CF.

April's TRIKAFTA Story

Watch April share her experience with TRIKAFTA and living with CF.

How TRIKAFTA™ works

How Does TRIKAFTA Work?

The 3 components of TRIKAFTA work together to target the underlying cause.

TRIKAFTA Safety Information

Learn about potential side effects.

Safety and side effects page

Get to Know Vertex GPS™:!break Guidance & Patient Support

Vertex GPS offers eligible patients ongoing one-on-one support, right from the start of treatment. Patient Support Specialists can help you navigate questions about insurance, reimbursement, and potential co-pay assistance. You can even get tips for your Vertex treatment and resources that may help you stay on track. No matter where you’re headed, Vertex GPS is with you along the way.