How Does TRIKAFTA® Work?
People with CF pictured
may or may not be
taking TRIKAFTA.
See How TRIKAFTA Works
Watch how the 3 components of TRIKAFTA work together to target the underlying cause.
View Important Safety Information and full Prescribing Information, including Patient Information, for TRIKAFTA.
See How TRIKAFTA Works
Watch how the 3 components of TRIKAFTA work together to target the underlying cause.
See How TRIKAFTA Works
Watch how the 3 components of TRIKAFTA work together to target the underlying cause.
View Important Safety Information and full Prescribing Information, including Patient Information, for TRIKAFTA.
The Underlying Cause
Cystic fibrosis (CF) is caused by mutations in the CF gene. These mutations lead to defects in a specific protein called the cystic fibrosis transmembrane conductance regulator (CFTR) protein. As a result of these defects, the CFTR proteins don’t work the way they should.
CF gene mutations cause one or both defects illustrated below:
Because of these defects, chloride ions cannot move into or out of the cells like they should. This can cause thick, sticky mucus to build up in organs, such as the lungs.
TRIKAFTA: Three Components That Work Together to Target the Underlying Cause
What is known about how TRIKAFTA works was learned from studies conducted in a laboratory. Keep in mind that results from laboratory studies do not always match how these medicines work in a person. If you have questions about your treatment, speak with your healthcare provider.
TRIKAFTA adds elexacaftor to tezacaftor and ivacaftor to target CFTR protein defects caused by the F508del mutation or another mutation responsive to TRIKAFTA.
Together, the 3 components help responsive CFTR proteins function better.
